Murasoli was started in Tiruvarur on 10 August 1942, during the World War II, by 18-year old M. Karunanidhi. Its earliest editions were in form of handwritten notices authored by Karunanidhi under the pen name "Cheran". The newspaper headquarters were moved to Chennai in 1954. From 17 September 1960, it has been published as a daily. As of 2017, the newspaper has a circulation of 70,000 copies.